Housed in a 16th-century fortress, the São Sebastião Museum is one of the oldest buildings in São Tomé. It showcases the island's history, including its colonial past, the transatlantic slave trade, and local culture through various exhibits and artifacts.

Obo National Park is a vast protected area covering much of São Tomé Island. It features dense tropical rainforest, volcanic peaks, and a rich diversity of flora and fauna, including many endemic species. Visitors can enjoy hiking, birdwatching, and exploring the island's natural beauty.

The Presidential Palace is an iconic colonial-era building located in the heart of São Tomé city. It serves as the official residence of the President of São Tomé and Príncipe and is notable for its impressive architecture and historical significance.

The Mercado Municipal is a vibrant local market where visitors can experience the daily life of São Tomé residents. It offers fresh produce, spices, crafts, and traditional foods, providing a colorful and authentic cultural experience.

Praia das Conchas is a beautiful beach located near São Tomé city, known for its clear waters and scenic views. It is a popular spot for swimming, relaxing, and enjoying the coastal environment.

This historic plantation, or 'roça,' offers insight into the island's colonial agricultural history. Visitors can tour the old coffee and cocoa plantations, learn about traditional farming methods, and enjoy the surrounding natural scenery.

Ilhéu das Rolas is a small island located just south of São Tomé Island, famous for being crossed by the equator. It features pristine beaches, clear waters, and opportunities for snorkeling and diving.

This historic fortress, built in the 16th century, is one of the oldest European buildings in the Gulf of Guinea. It offers panoramic views of the city and harbor and provides a glimpse into the island's colonial military history.

The National Library houses a collection of books, manuscripts, and documents related to the history and culture of São Tomé and Príncipe. It is a valuable resource for researchers and visitors interested in the island's heritage.

Santana Beach is a tranquil beach area near São Tomé city, ideal for swimming and enjoying the natural coastal environment. It is less crowded than some other beaches, offering a peaceful retreat.